金沢大学 薬物動態学研究室

金沢大学 薬物動態学研究室

更新情報・お知らせ

2024/02/16
Pharmacology & Therapeuticsに総説が採択されました. Wen et al., "Uric acid in health and disease: From physiological functions to pathogenic mechanisms."
2023/12/29
J Pharm Sciに論文が採択されました. Sugiyama et al., "The Use of Carboxyfluorescein Reveals the Transport Function of MCT6/SLC16A5 Associated with CD147 as a Chloride-Sensitive Organic Anion Transporter in Mammalian Cells."
2023/12/12
Biopharm Drug Disposに論文が採択されました. Yasugi et al., "Quantitative analysis of the impact of membrane permeability on intestinal first-pass metabolism of CYP3A substrates"
2023/11/16
Mol Pharmに論文が採択されました. Kiyomiya et al., "Macrolide and Ketolide Antibiotics Inhibit the Cytotoxic Effect of Trastuzumab Emtansine in HER2-Positive Breast Cancer Cells: Implication of a Potential Drug-ADC Interaction in Cancer Chemotherapy"
2023/11/14
Biol Pharm Bullに論文が採択されました. Takemura et al., "Magnitude of Fruit Juice-Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices."
2023/10/14
Scientific Reportsに論文が採択されました. Funai et al., "Quantitative analysis of gastrointestinal fluid absorption and secretion to estimate luminal fluid dynamics in rats"
2023/10/13
J Stroke Cerebrovasc Disに論文が採択されました. Sumiya et al., "Association between switching prescribed drugs for lower urinary tract symptoms and independence of urination in post-stroke patients: A retrospective cohort study"
2023/08/29
Drug Metabolism & Dispositionに論文が採択されました. Fujita et al., "Potentiation of the Uricosuric Effect of Dotinurad by Trans-Inhibition of the Uric Acid Reabsorptive Transporter URAT1."
2023/07/19
Communications Biologyに論文が採択されました. Arakawa, Nakazono et al., "Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion."
2023/06/29
Drug Metabolism & Disposに論文が採択されました. Ishiguro et al., "Improvement of protein expression profile in three-dimensional renal proximal tubular epithelial cell spheroids selected based on OAT1 gene expression: a potential in vitro tool for evaluating human."
2023/05/02
Food & Functionに論文が採択されました. Zhu et al., "Apple juice relieves loperamide-induced constipation in rats by downregulating the intestinal apical sodium-dependent bile acid transporter ASBT."
2023/04/25
Drug Metabolism and Pharmacokineticsに論文が採択されました. Usui et al., "Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα."
2023/04/20
The AAPS Journal に論文が採択されました. Suzuki et al., "Quantitative Analysis of Gastrointestinal Water Dynamics by Means of a Physiologically Based Fluid Kinetic Model."
2023/04/01
創薬科学類生 4名、薬学類生 3名 研究室に配属されました.
2023/03/22
学位記伝達式が執り行われました.
2023/03/01
Molecular Pharmacologyに論文が採択されました. Miyazaki et al., "The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane."
2023/02/01
Drug Metabolism and Pharmacokineticsに論文が採択されました. Kambayashi and Shirasaka., "The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane."
2023/01/30
Pharmaceuticsに論文が採択されました. Sato et al., "Biological Distribution after Oral Administration of Radioiodine-Labeled Acetaminophen to Estimate Gastrointestinal Absorption Function via OATPs, OATs, and/or MRPs."
2023/01/02
Molecular Pharmaceuticsに論文が採択されました. Tomabechi et al., "Identification of 5-Carboxyfluorescein as a Probe Substrate of SLC46A3 and Its Application in a Fluorescence-Based In Vitro Assay Evaluating the Interaction with SLC46A3."
2022/12/29
Frontiers in Pharmacologyに論文が採択されました. Sato et al., "A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells."
2022/05/20
PNAS Nexusに論文が採択されました. Tomabechi et al., "SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM1."
2022/05/01
Journal of Pharmaceutical Sciencesに論文が採択されました. Shirasaka et al., "Multiple Transport Mechanisms Involved in the Intestinal Absorption of Metformin: Impact on the Nonlinear Absorption Kinetics."
2022/05/01
European Journal of Pharmaceutical Sciencesに論文が採択されました. Funai et al., "Effect of ingested fluid volume and solution osmolality on intestinal drug absorption: Impact on drug interaction with beverages."
2022/04/01
創薬科学類生 4名、薬学類生 2名、博士課程(薬学専攻) 1名 研究室に配属されました.
2022/03/22
学位記伝達式が執り行われました.
2022/03/03
Pharmaceutical Researchに論文が採択されました. Kadoguchi et al., "Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening."
2022/02/24
Journal of Medicinal Chemistryに論文が採択されました. Konno et al., "3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents."
2022/01/07
Journal of Pharmaceutical Sciencesに論文が採択されました. Shirasaka et al., "Multiple Transport Mechanisms Involved in the Intestinal Absorption of Metformin: Impact on the Nonlinear Absorption Kinetics."
2021/12/24
Pharmaceuticsに論文が採択されました. Kobayashi et al., "Biological Distribution of Orally Administered [123I]MIBG for Estimating Gastrointestinal Tract Absorption."
2021/12/23
Biological and Pharmaceutical Bulletinに論文が採択されました. Arakawa et al., "Evaluation of Platinum Anticancer Drug-Induced Kidney Injury in Primary Culture of Rat Kidney Tissue Slices by Using Gas-Permeable Plates."
2021/10/01
Biochemical and Biophysical Research Communicationsに論文が採択されました. Wen et al., "CD38 activation by monosodium urate crystals contributes to inflammatory responses in human and murine macrophages."
2021/07/18
Pharmaceutical Researchに論文が採択されました. Suzuki et al., "Model Analysis of the Apparent Saturation Kinetics of Purine Nucleobase Uptake in Cells co-Expressing Transporter and Metabolic Enzyme."
2021/06/10
Journal of Pharmaceutical Health Care and Sciencesに論文が採択されました. Takemura et al., "Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation."
2021/06/01
Drug Metabolism & Dispositionに論文が採択されました. Komori et al., "MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion-Transporting Peptide 2B1/ SLCO2B1 in Caco-2 Cells."
2021/05/01
Biological and Pharmaceutical Bulletinに論文が採択されました. Nakazono, Arakawa et al., "Drug Transcellular Transport Assay Using a High Porosity Honeycomb Film."
2021/04/12
Journal of Medicinal Chemistryに論文が採択されました. Konno et al., "3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents."
2021/02/18
Drug Metabolism & Dispositionに論文が採択されました. Cai et al., "Identification of Triterpene Acids in Poria cocos Extract as Bile Acid Uptake Transporter Inhibitors."
2021/02/17
Pharmaceutical Researchに論文が採択されました. Arai et al., "Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo."
2020/11/25
Journal of Pharmaceutical Sciencesに論文が採択されました. Zhu et al., "A Novel Fluorescence-Based Method to Evaluate Ileal Apical Sodium-Dependent Bile Acid Transporter ASBT."
2020/09/28
Nuclear Medicine and Biologyに論文が採択されました. Kobayashi et al., "[131I] MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I] MIBG in neuroblastoma."
2020/08/20
Toxicology and Applied Pharmacologyに論文が採択されました. Nakanishi et al., "Toxicological implication of prostaglandin transporter SLCO2A1 inhibition by cigarette smoke in exacerbation of lung inflammation."
2020/08/19
Biological and Pharmaceutical Bulletinに論文が採択されました. Arakawa et al., "Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9."
2020/08/18
Drug Metabolism and Pharmacokineticsに論文が採択されました. Liu et al., " Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24."
2020/06/22
Drug Metabolism and Pharmacokineticsに論文が採択されました. Wada et al., "Mathematical modeling analysis of hepatic uric acid disposition using human sandwich-cultured hepatocytes."
2020/04/30
オンライン歓迎会
2020/04/27
iScienceに論文が採択されました. Inagaki et al., "Contribution of prostaglandin transporter OATP2A1/SLCO2A1 to placenta-to-maternal hormone signaling and labor induction."
2020/04/01
白坂 善之 准教授が着任されました.
2020/04/01
創薬科学類生 4名、薬学類生 3名、博士課程(薬学専攻) 3名 研究室に配属されました.
2020/03/22
学位記伝達式が執り行われました.
2020/03/10
Molecular pharmaceuticsに論文が採択されました. Hirayama et al., "Identification of the Uptake Transporter Responsible for Distribution of Acotiamide into Stomach Tissue."
2019/11/22
山窓会開催情報を更新しました
2019/11/13
第28回山窓会 会場アクセスをアップしました
2019/10/28
Scientific Reportsに論文が採択されました. Kobayashi et al., "Imaging of hepatic drug transporters with [131I]6-β-iodomethyl-19-norcholesterol."
2019/10/28
Scientific Reportsに論文が採択されました. Ishii et al., "Identification of the Catechin Uptake Transporter Responsible for Intestinal Absorption of Epigallocatechin Gallate in Mice."
2019/09/14
第28回山窓会を2019年11月23日に開催します.
2019/04/05
Journal of Pharmaceutical Sciencesに論文が採択されました. Arakawa et al., "Rat Kidney Slices for Evaluation of Apical Membrane Transporters in Proximal Tubular Cells."
2019/04/05
PLoS Oneに論文が採択されました. Nishizawa et al., "Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia."
2019/04/01
中西猛夫先生がご栄転されました.

2018 International Meeting on 22nd MDO and 33rd JSSX

第39回生体膜と薬物の相互作用シンポジウム

薬物動態学研究室
〒920-1192
石川県金沢市角間町