金沢大学 薬物動態学研究室

Achievement 2008: Regular articles

  1. Morimoto K, Nakakariya M, Shirasaka Y, Kakinuma C, Fujita T, Tamai I, Ogihara T. Oseltamivir (TamifluTM) efflux transport at the blood-brain barrier via P-glycoprotein. Drug Metab Dispos, 36: 6-9 (2008).
  2. Otake K, Suzuki H, Higashi R, Yabuuchi H, Haga M, Maeda T, Cook TJ, Tamai I. Improved intestinal membrane permeability of hexose-quinoline derivatives via the hexose transporter, SGLT1. J Pharm Sci, 97: 1821-1830 (2008).
  3. Sato M, Iwanaga T, Mamada H, Ogihara T, Maeda T, Tamai I. Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res, 25: 639-646 (2008).
  4. Ishiguro N, Oyabu O, Sato T, Maeda , Minami H., Tamai I. Decreased biosynthesis of lung surfactant constituent phosphatidylcholine due to inhibition of choline transporter by gefitinib in lung alveolar cells. Pharm Res, 25: 417-427 (2008).
  5. Nakakariya M, Shimada D, Koibuchi H, Irokawa M, Iwanaga T, Yabuuchi H, Maeda T, Tamai I. Characterization of Oatp-mediated hepatic uptake of nafcillin, a high biliary excretion type of β-lactam antibiotics. Pharm Res, 25: 578-585 (2008).
  6. Tani T, Gram LK, Arakawa H, Kikuchi A, Chiba M, Ishii Y, Steffansen B, Tamai I. Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats. Phram Res, 25: 1085-1091 (2008).
  7. Maeda T, Yotsumoto T, Oyabu M, Tamai I. Effect of glucocorticoid receptor ligand dexamethasone on the expression of the organic cation transport in rat liver. Drug Metab Pharmacokinet, 23: 67-72 (2008).
  8. Fukuda H, Ohashi R, Tsuda-Tsukimoto M, Tamai I. Effect of plasma protein binding on in vitro-in vivo correlation of biliary excretion of drugs evaluated by sandwich-cultured rat hepatocytes. Drug Metab Dispos, 36: 1275-1282 (2008).
  9. Kato Y, Takahara S, Kato S, Kubo Y, Sai Y, Tamai I, Yabuuchi H, Tsuji A. Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of ß-lactam antibiotics. Drug Metab Dispos, 36: 1088-1096 (2008).
  10. Nakamura T, Yoshida K, Yabuuchi H, Maeda T, Tamai I. Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4). Biol Pharm Bull, 31: 1580-1584 (2008).
  11. Maeda T, Wakasawa T, Funabashi M, Fukushi A, Fujita M, Motojima K, Tamai I. Regulation of Octn2 transporter (SLC22A5) by peroxisome proliferator activated receptor alpha. Biol Pharm Bull, 31: 1230-1236 (2008).
  12. Maeda T, Shima Y, Sugiura S, Aizawa S, Tamai I. Changes of differentiation and proliferation in K562 cells with various levels of knockdown of cationic amino acid transporter 1. Drug Metab Pharmacokinet, 23: 181-187 (2008).
  13. Li Y, Sato M, Yanagisawa Y, Mamada H, Fukushi A, Mikami K, Shirasaka Y, Tamai I. Effects of angiotensin II receptor blockers on renal handling of uric acid in rats. Drug Metab Pharmacokinet, 23: 263-270 (2008).
  14. Nakakariya M, Shimada T, Irokawa M, Maeda T, Tamai I. Identification and species similarity of OATP transporters responsible for hepatic uptake of ß-lactam antibiotics. Drug Metab Pharmacokinet, 23: 347-355 (2008).
  15. Yabuuchi H, Takemura M, Oka M, Ohashi R, Tamai I. Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins. Biopharm Drug Dispos, 29: 441-448 (2008).
  16. Kikuchi A, Tanaka M, Tomoyasu T, Maeda M, Tamai I. Improvement of intestinal absorption by peptide-derivation of nonabsorbable drug via peptide transporter PEPT1. J Pharm Sci, 98: 1775-1787 (2008).

2018 International Meeting on 22nd MDO and 33rd JSSX

第39回生体膜と薬物の相互作用シンポジウム

薬物動態学研究室
〒920-1192
石川県金沢市角間町