金沢大学 薬物動態学研究室

Achievement 2012: Regular articles

  1. Saheki A, Seki J, Nakanishi T, Tamai I. Effect of back pressure on emulsification of lipid nanodispersions in a high-pressure homogenizer. Int J Pharm, 422: 489-494 (2012).
  2. Yashio K, Katayama Y, Takashima T, Ishiguro N, Doi H, Suzuki M, Wada Y, Tamai I, Watanabe Y. Synthesis of [¹¹C]uric acid, using [¹¹C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout. Bioorg Med Chem Lett, 22: 115-119 (2012).
  3. Maeda H, Kodaira H, Fujita K, Kobayashi H, Ushiki J, Nakanishi T, Tamai I. Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno [3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals. Xenobiotica, 42: 649-659 (2012).
  4. Maeda H, Fujita K, Kobayashi H, Ushiki J, Nakanishi T, Tamai I. Novel LC-MS/MS method for simultaneous quantification of KW-7158, a new drug candidate for urinary incontinence and bladder hyperactivity, and its metabolites in rat plasma: A pharmacokinetic study in male and female rats. Arzneimittelforschung, 62: 213-221 (2012).
  5. Hosomi A, Nakanishi T, Fujita T, Tamai I. Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. PLoS One, 7: e30456 (2012).
  6. Shirasaka Y, Mori T, Shichiri M, Nakanishi T, Tamai I. Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites. Drug Metab Pharmacokinet, 27: 360-364 (2012).
  7. Sakuma S, Kanamitsu S, Teraoka Y, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y, Tamai I, Muraoka M, Nakatsuji Y, Kida T, Akashi M. Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na⁺/glucose cotransporter 1 (SGLT1)-mediated D-glucose uptake. Mol Pharm, 9: 922-929 (2012).
  8. Nakanishi T, Ikenaga M, Fukuda H, Matsunaga N, Tamai I. Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug-drug interaction induced by liver metabolites. Toxicol Appl Pharmacol, 263: 244-250 (2012).
  9. Arakawa H, Nakanishi T, Yanagihara C, Nishimoto T, Wakayama T, Mizokami A, Kawai K, Tamai I. Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions. Biochem Pharmacol, 84: 1070-1077 (2012).
  10. Arakawa H, Shirasaka Y, Haga M, Nakanishi T, Tamai I. Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5. Biopharm Drug Dispos, 33: 332-341 (2012).
  11. Hiyama K, Matsui H, Tamura M, Shimokawa O, Hiyama M, Kaneko T, Nagano Y, Hyodo I, Tanaka J, Miwa Y, Ogawa T, Nakanishi T, Tamai I. Cancer cells uptake porphyrins via heme carrier protein 1. J Porphyrins Phthalocyanines, 16: 1-8 (2012).

2018 International Meeting on 22nd MDO and 33rd JSSX

第39回生体膜と薬物の相互作用シンポジウム

薬物動態学研究室
〒920-1192
石川県金沢市角間町