金沢大学 薬物動態学研究室

Achievement 2015: Regular Articles

  1. Lu Y, Nakanishi T, Hosomi A, Komori H, Tamai I. In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells. J Pharm Pharmacol, 67(2): 170-177 (2015).
  2. Nguyen MA, Staubach P, Tamai I, Langguth P. High-dose short-term administration of naringin did not alter talinolol pharmacokinetics in humans. Eur J Pharm Sci, 68: 36-42 (2015).
  3. Matsunaga N, Suzuki K, Nakanishi T, Ogawa M, Imawaka H, Tamai I. Modeling approach for multiple transporters-mediated drug-drug interaction in sandwich-cultured human hepatocytes: Effect of cyclosporine A on hepatic disposition of mycophenolic acid phenyl-glucuronide. Drug Metab Pharmacokinet, 30: 142-148 (2015).
  4. Watanabe M, Watanabe T, Yabuki M, Tamai I. Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys. Drug Metab Pharmacokinet, 30: 198-204 (2015).
  5. Matsumoto J, Ariyoshi N, Sakakibara M, Nakanishi T, Okubo Y, Shiina N, Fujisaki K, Nagashima T, Nakatani Y, Tamai I, Yamada H, Takeda H, Ishii I. Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells. Drug Metab Pharmacokinet, 30(2):133-141 (2015).
  6. Nakanishi T, Hasegawa Y, Mimura R, Wakayama T, Uetoko Y, Komori H, Akanuma S, Hosoya K, Tamai I. Prostaglandin transporter (PGT/SLCO2A1) protects the lung from bleomycin-induced fibrosis. PLoS One, 10(4): e0123895 (2015).
  7. Nakanishi T, Ogawa T, Yanagihara C, Tamai I. Kinetic evaluation of determinant factors for cellular accumulation of protoporphyrin IX induced by external 5-aminolevulinic acid for photodynamic cancer therapy. J Pharm Sci, 104(9): 3092-3100 (2015).
  8. Akamine Y, Miura M, Komori H, Tamai I, Ieiri I, Yasui-Furukori N, Uno T. The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion. Drug Metab Pharmacokinet, 30(5): 352-357 (2015).
  9. Takahashi K, Yoshisue K, Chiba M, Nakanishi T, Tamai I. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluridine using human small intestinal epithelial cells. J Pharm Sci, 104(9): 3146-3153 (2015).
  10. Shimada T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Shimada T, Sawamoto K, Miyamoto KI, Kitagawa H, Ohta T, Tamai I, Sai Y. Saturable hepatic excretion of gemcitabine involves biphasic uptake mediated by nucleoside transporters equilibrative nucleoside transporter 1 and 2. J Pharm Sci, 104(9): 3162-3169 (2015).
  11. Shimada H, Nakamura Y, Nakanishi T, Tamai I. OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion. Biochem Pharmacol. 98(4): 629-638 (2015).

2018 International Meeting on 22nd MDO and 33rd JSSX

第39回生体膜と薬物の相互作用シンポジウム

薬物動態学研究室
〒920-1192
石川県金沢市角間町