Achivements: 2023

2023

1. Usui S, Zhu Q, Komori H, Iwamoto Y, Nishiuchi T, Shirasaka Y, and Tamai I. Apple-derived nanoparticles modulate expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα. Drug Metab Pharmacokinet, 52:100512 (2023).

2. Zhu Q, Iwai R, Okaguchi T, Shirasaka Y, and Tamai I. Apple juice relieves loperamide-induced constipation in rats by downregulating intestinal apical sodium-dependent bile acid transporter ASBT. Food Funct, 14(10):4836-4846 (2023).

3. Suzuki S, Inoue K, Tamai I, and Shirasaka Y. Quantitative analysis of gastrointestinal water dynamics by means of a physiologically based fluid kinetic model. AAPS J, 25(3):42 (2023).

4. Miyazaki K, Kishimoto H, Kobayashi H, Suzuki A, Higuchi K, Shirasaka Y, and Inoue K. The glycosylated N-terminal domain of MUC1 is involved 1 in chemoresistance by modulating drug permeation across the plasma membrane. Mol Pharmacol, 103(3): 166-175 (2023).

5. Kambayashi A and Shirasaka Y. Food effects on gastrointestinal physiology and drug absorption. Drug Metab Pharmacokinet, 48: 100488 (2023).

6. Sato K, Seki T, Mizutani A, Muranaka Y, Hirota S, Nishi K, Yamazaki K, Nishii R, Nakanishi T, Tamai I, Kawai K, Kobayashi M. A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells. Frontiers in Pharmacology, 13:1069321 (2023).

7. Tomabechi R, Miyasato M, Sato T, Takada T, Higuchi K, Kishimoto H, Shirasaka Y, and Inoue K. Identification of 5-carboxyfluorescein as a probe substrate of SLC46A3 and its application in a fluorescence-based in vitro assay evaluating the interaction with SLC46A3. Mol Pharm, 20(1):491-499 (2023).

8. Sato K, Mizutani A, Muranaka Y, Yao J, Kobayashi M, Yamazaki K, Nishii R, Nishi K, Nakanishi T, Tamai I, Kawai K. Biological Distribution after Oral Administration of Radioiodine-Labeled Acetaminophen to Estimate Gastrointestinal Absorption Function via OATPs, OATs, and/or MRPs. Pharmaceutics, 15:497 (2023).

9. Ishiguro N, Takahashi E, Arakawa H, Saito A, Kitagawa F, Kondo M, Morinaga G, Takatani M, Takahashi R, Kudo T, Mae S, Kadoguchi M, Higuchi D, Nakazono Y, Tamai I, Osafune K, and Jimbo Y. Improvement of Protein Expression Profile in Three-Dimensional Renal Proximal Tubular Epithelial Cell Spheroids Selected Based on OAT1 Gene Expression: A Potential In Vitro Tool for Evaluating Human Renal Proximal Tubular Toxicity and Drug Disposition. Drug Metab Dispos, 51(9):1177-1187 (2023).

10. Arakawa H, Nakazono Y, Matsuoka N, Hayashi M, Shirasaka Y, Hirao A, and Tamai I. Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion. Commun Biol, 6: 866 (2023).

11. Fujita K, Zhu Q, Arakawa H, Shirasaka Y, and Tamai I. Potentiation of the Uricosuric Effect of Dotinurad by Trans-Inhibition of the Uric Acid Reabsorptive Transporter URAT1. Drug Metab. Dispos, 51(11):1527-1535 (2023).

12. Sumiya K, Shogenji M, Ikenaga Y, Ogawa Y, Hirako K, Fujita A, Shimada T, Hashimoto M, Masuda A, Nagamoto T, Tamai I, Ogura H, Toyama T, Wada T, and Sai Y. Association between switching prescribed drugs for lower urinary tract symptoms and independence of urination in post-stroke patients: A retrospective cohort study. J Stroke Cerebrovasc Dis, 32(12):107419 (2023).

13. Funai Y, Ichijo K, Suzuki S, Tateishi Y, Inoue K, Tamai I, and Shirasaka Y. Quantitative analysis of gastrointestinal fluid absorption and secretion to estimate luminal fluid dynamics in rats. Sci Rep, 13(1):17454 (2023).

14. Kiyomiya K, Tomabechi R, Saito N, Watai K, Takada T, Shirasaka Y, Kishimoto H, Higuchi K, Inoue K. Macrolide and Ketolide Antibiotics Inhibit the Cytotoxic Effect of Trastuzumab Emtansine in HER2-Positive Breast Cancer Cells: Implication of a Potential Drug-ADC Interaction in Cancer Chemotherapy. Mol Pharm, doi : 10.1021/acs.molpharmaceut.3c00490 (2023).

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